b'C E N T E R F O R R E S I L I E N C EC A R D I O V A S C U L A R D I S E A S E A N D R I S K F A C T O R SREDUCEDOne hundred and three coronary heart disease patients METABOLICwere randomly assigned to Transcendental Meditation (TM) SYNDROME or health education (HE) control group. Over a four-month Archives of Internalintervention period, the TM group showed a significant Medicine, 2006, 166, 1218- improvement in blood pressure and insulin resistance 1224 (American Medicalcomponents of the metabolic syndrome as well as cardiac Association journal) autonomic nervous system tone compared to HE. These results suggest that TM may modulate the physiological response to stress and improve coronary heart disease risk factors.RESEARCH FIELD SITE: Cedars-Sinai Medical Center, CANational Institutes of HealthNational Heart, Lung and National Center for Complementary and Alternative Medicine and other National Institutes of Health Grants R01 AT00226, 1-P50-AA0082-02, 1-R15-HL660242- 01, R01-HL51519-08IMPROVEDFifty-six coronary heart disease (CHD) African American patients MYOCARDIAL FLOWwere assigned to standard cardiac rehabilitation (CR), CR+TM RESERVE (Transcendental Meditation), TM alone, or usual care. Testing was Journal of Nucleardone at baseline and after 12 weeks. The primary outcome was Cardiology, 2019,myocardial flow reserve (MFR) assessed by 13 N-ammonia positron doi:10.1007/s12350-019- emission tomography (PET). For the combined TM group, MFR 01884-9 increased (+14%, ES=0.56) compared to the combined non-TM group (-2.0%, ES=-0.08). These pilot data suggest that adding the TM technique to standard cardiac rehabilitation or using TM alone may improve the myocardial flow reserve in African American CHD patients. RESEARCH FIELD SITE: Columbia University Medical Center, New York, NYNational Heart Lung and Blood Institute Grant HL 10038628'